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KMID : 0385520140270050223
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Analytical Science & Technology
2014 Volume.27 No. 5 p.223 ~ p.227
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Analysis of the effects of δ-Aminolevulinic acid on the proliferation and apoptosis of mammalian cells
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Jun Yong-Woo
Kim Kun-Hyung
Jang Deok-Jin
Jo Su-Yeon
Lee Jin-A
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Abstract
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δ-Aminolevulinic acid (ALA) is a compound which is widely present in the biosphere and plays an important role in the living body as an intermediate of the tetrapyrrole compound biosynthesis pathway that leads to heme in mammals and chlorophyll in plants. ALA is of interest as a biodegradable mediator, a growth regulator, a precursor of heme proteins, and an effective agent used in therapy of cancer. It has been recently reported that ALA is commonly used in dermatology, due to good effects of skin therapy. Although for the last few decades a substantial amount of research has been focused on the elucidation of the mechanism of ALA and the improvement of its therapeutic activity, it’s effect on the cell functions and growth was not cleared. Here, we identified that ALA treatment could attenuate cell proliferation of HEK293T and HaCaT
cells. In addition, ALA treatement could induce apoptosis of HeLa cells. These results suggest that apoptosis induced by ALA treatment might be responsible for inhibition of cell proliferation. These results propose the possibility of the improved therapeutic strategy making ALA one of the effective drugs used in human cancers
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KEYWORD
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δ-Aminolevulinic acid, Apoptosis, cell proliferation, cell growth,
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